PHENYLPROPANOLAMINE HYDROCHLORIDE
DL-Norephedrine hydrochloride
CAS: 154-41-6
Molecular Formula: C9H14ClNO
PHENYLPROPANOLAMINE HYDROCHLORIDE - Names and Identifiers
| Name | DL-Norephedrine hydrochloride |
| Synonyms | NOREPHEDRINE HCL PHENYLPROPANOLAMINE HCL NOREPHEDRINE HYDROCHLORIDE DL-Norephedrine hydrochloride PHENYLPROPANOLAMINE HYDROCHLORIDE |
| CAS | 154-41-6 |
| EINECS | 205-826-7 |
PHENYLPROPANOLAMINE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C9H14ClNO |
| Molar Mass | 187.67 |
| Density | 1.0969 (rough estimate) |
| Melting Point | 194-196°C(lit.) |
| Solubility | Dissolve 1.25 g in water R and dilute to 25 mL with the same solvent. |
| Merck | 13,7391 |
| pKa | 9.44(at 25℃) |
| Storage Condition | -20°C |
| Refractive Index | 1.5330 (estimate) |
| Physical and Chemical Properties | Melting point 190-194 ℃, soluble in water and alcohol, insoluble in ether, chloroform and benzene. The melting point of phenylpropanolamine base ([492-41-1]) is 101-101.5°C. |
PHENYLPROPANOLAMINE HYDROCHLORIDE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S7 - Keep container tightly closed. |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| RTECS | DN4200000 |
| HS Code | 29394900 |
| Toxicity | LD50 orally in rats: 1490 mg/kg (Goldenthal) |
PHENYLPROPANOLAMINE HYDROCHLORIDE - References
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| purpose | This product is a nasal decongestant, appetite-reducing agent. DL-phenylpropanolamine hydrochloride is a nasal decongestant and an appetite-reducing agent. |
| production method | US patent 2151517 describes the following methods: A 50 L aqueous solution of 10.7 of benzaldehyde and 11.0 of sodium bisulfite was vigorously shaken until complete formation of the addition product. At the same time, 8.25 of nitroethane was dissolved in 20 liters of aqueous solution of 4.5 of caustic soda, and the obtained hot solution was added to the thick liquid of sodium benzenesulfite under strong stirring, after the mixture was shaken for half an hour and left overnight, a small amount of unreacted Benzaldehyde was removed from the oily phenylnitropropanol floating in the upper layer with 11.0 of a 50 liter aqueous solution of sodium bisulfite. Phenylnitropropanol was obtained as no common oil. Weight 17.1-17.7, boiling point 150-165 deg C (0.66 5千帕). The radical is hydrogenated and converted to the hydrochloride salt, I .e. phenylpropanolamine hydrochloride. |
Last Update：2024-04-09 02:00:18
